Management in Health, Vol 22, No 2 (2018)

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BRAIN ATROPHY AND NEUROCOGNITIVE RESERVE- THE FIRST ROMANIAN CLINICAL STUDY

Maria MOGLAN, Raluca Oana TIPA, Voicu BOSCAIU, Mihaela ROCO, Catalina TUDOSE

Abstract


BACKGROUND:

The cognitive reserve hypothesis explains the ability to tolerate the age-related changes and the disease related pathology in the brain without developing clear clinical symptoms or signs. Persons with a low educational level present earlier clinical symptoms of neuropathology disorders. The brain reserve moderates the relationship between changes at brain level and neuropathology disorders. Cognitive reserve could compensate the deterioration of the brain.

OBJECTIVE:

This study investigates the relationship between cognitive impairment level, the severity of brain atrophy and the level of education on a sample of 235 individuals with cognitive complains, who required neurocognitive evaluation at Bucharest Memory Center between 2011 to 2016.

METHODS:

A retrospective study was conducted over six years based on the medical records of those who addressed the Center for Memory for neurocognitive assessment in order to establish the diagnosis. The socio-demographic parameters were recorded along with educational level, the brain atrophy presence, the psychiatric diagnosis and cognitive decline.

RESULTS:

The cognitive reserve hypothesis was verified, unless the MMSE score was very low (for severe neurocognitive disorder). Thus, the cognitive reserve theory is confirmed by the relationship between the educational level and the Mini Mental Score Evaluation (MMSE) score (the higher the educational level is, the higher the MMSE score is).

 

Keywords: Brain atrophy, cognitive reverve, educational level, neurocognitive disorder


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