Management in Health, Vol 20, No 3 (2016)

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Non-Invasive Ventilation Decreases the Blood Level of Paco2, but Increases the Levels of Pao2 and Sao2 in Albanian Patients with Chronic Obstructive Pulmonary Disease and Acute Respiratory Failure

Epaminonda FYPE, Ornela NUREDINI, Mimoza GOGA, Armela CUKO, Rinard, KERTOCI, Ilir SKENDULI, Ilir OHRI


BACKGROUND: The aim of this study was to compare the partial pressure of carbon dioxide (PaCO2), the partial pressure of oxygen (PaO2) in the blood, and the arterial oxygen saturation (SaO2) between patients with chronic obstructive pulmonary disease (COPD) and acute respiratory failure undergoing non-invasive ventilation (NIV) and their counterparts under conventional therapy.

METHODS: This study was conducted at the University Hospital of Lung Diseases “Shefqet Ndroqi” in Tirana during 2011-2014 including 250 patients diagnosed with COPD and acute respiratory failure. Patients were divided into two groups: 125 patients were administered NIV, whereas 125 patients underwent the standard (conventional) treatment procedure. Mann-Whitney U-test was used to compare the mean values of PaCO2, PaO2 and SaO2 between the two groups of patients both upon hospital admission and hospital discharge.   

RESULTS: Upon hospital discharge, mean value of PaCO2 was significantly lower in patients who were administered NIV compared with those who underwent the standard/conventional therapy (46.4±1.9 vs. 58.6±2.3, respectively; P

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