Management in Health, Vol 18, No 1 (2014)

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ASSOCIATION BETWEEN AgNORs AND IMMUNOHISTOCHEMICAL EXPRESSION Of COX2 and iNOS IN BLADDER CANCER

Hassan Elsiddig Hassan FARAGALLA, Hussain Gadelkarim AHMED, Ahmed AbdelBadie MOHAMED, Amel Omer BAKHIET, Faris Mohammednour ALTAF, Abdella EmamAbdella BARAGOB, Ashraf Mohamed Elsayed Ali SAKRAN

Abstract


OBJECTIVE: The objective of this study was to find out if there is correlation between AgNORs (Argyrophilic Nucleolar Organizer Region-associated proteins), COX2 and iNOS expression in bladder cancer

METHODOLOGY: The present study investigated the relationship between means AgNORs count and immunohistochemical expression of COX2 and iNOS in bladder carcinomas in serial paraffin sections from 155 bladder carcinomas. Thirty nine control cases of benign bladder cystitis lesions were included.

RESULTS: Mean AgNOR counts correlated significantly with COX2 and iNOS, denoting P values of 0.000 for all three markers. Mean AgNOR count was significantly correlated with tumor type; the mean was 5.94 for SCC, 4.94 for TCC and 3.72 for benign bladder cystitis.

CONCLUSION: Strong link between cell proliferation and cellular proliferative activity. Thus the three investigated markers (AgNORs, COX2 and iNOS) can be used as pre-warning factors of bladder cancers among patients at risk of bladder cancer.

Keywords: Ag NORs, COX2. iNOS, Bladder cancer.


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